Achi news desk-
Cytiva introduced its Xcellerex magnetic mixer at the annual Interphex meeting in New York City this week. The single mixing system is specifically designed to address challenges faced by customers involved in the large-scale manufacturing processes of monoclonal antibodies, vaccines and genomic medicine, according to Amanda Halford, president, bioprocess, Cytiva. Sized in 2000 and 3000 L capacities, the mixer offers several configurations to accommodate various mixing processes, he adds.
“We leverage our differentiated portfolio to solve a wide range of challenges for our customers,” continued Halford. “Our new magnetic mixing system is flexible and able to meet the many requirements and constraints during the preparation of buffer and cell culture media. By reimagining the design, we’ve addressed some of the biggest barriers to downtime.”
Leakages are a major contributor to losses of time and money. A small spill can cause or lead to a major setback – it can mean the loss of a full working day for our customers, said Jon Van Pelt, vice president, bioprocess disposable technologies, Cytiva. When dealing with a 3000 L batch of cell culture media, the estimated financial loss can cost between $60k more than $100k. That’s just the material and labor. It doesn’t take into account the opportunity cost and other effects caused by not having media available for your cell culture processes, Van Pelt continued.
Biocontainer mixer
To help prevent leaks, the system includes a blender biocontainer that incorporates user-centered design elements aimed at strengthening durability and improving ease of use. This evolution in design results in improved safety measures, providing additional protection against leaks throughout transportation, storage and operation, Halford said.
Another limitation during the development of drug therapies is the quality and time it takes to mix a batch. Mixing floating powders, such as cell culture media, can be a challenge with many of the mixing systems currently available, says Halford, pointing out that most of these systems have underpowered impellers. and a less-than-ideal circular or cubical shape, especially for large production volumes. Powder tends to float on the surface of the liquid, making it difficult to mix evenly into the liquid or leading to long mixing times.
The new mixing system has an impeller which when combined with the hexagonal shape of the mixer creates a vortex, improving the interaction on the liquid surface, according to Van Pelt. This vortex effectively pulls the floating powders into the main body of the liquid to allow for a more efficient and shorter mixing process, he explained.
“Process engineers and scientists, who currently struggle with tight facility constraints or complex large-scale consumable installation, will benefit from its compact size, allowing it to fit into tight facility spaces without compromising on capacity or need to expand facilities,” says Van Pelt. “We’re always listening to our customers – solving problems to get life-changing therapies to patients faster.”
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